一．教育经历

时间学校专业学位

2003,8-2008,2新加坡新加坡国立大学医学院肿瘤分子生物学博士

1986,9-1989,7广州中山大学生物工程研究中心植物基因工程硕士

1982, 9-1986, 7 广州中山大学 生物系植物学学士

二．工作经历

职位 时间 地点 单位

教授 2016.4-现在 中国龙岩威尼斯人91111

教授 2012.11-2016.3 中国常州 常州大学生物医学工程与健康科学研究院

研究员((Senior) Research Fellow) 2005, 2- 2012.10新加坡新加坡国立大学医学院

(School of Medicine, NUS)

2000, 5-2005, 1 新加坡

约翰霍普金斯-新加坡

(Johns Hopkins Singapore)

讲师 1996, 9-2000, 4 中国广州中山大学生物工程研究中心

研究助理(Research Assistant) 1994, 9-1996, 8 中国香港

香港科技大学研究中心(Research Center, The Hong Kong University of Science & Technology)

助教、讲师 1989, 8-1994, 8 中国广州 中山大学生物工程研究中心

三．研究方向或领域

1.病毒基因组3’非编码区对猪繁殖与呼吸综合征病毒毒力的调控作用；2.野鸦椿有效成分对细菌和病毒的抑制作用及其在生产中的应用。

四．近五年主持科研项目

1.上杭县奇迈科技创新基金项目，2020SHQM11，野鸦椿规模化繁育栽培及其在河田鸡养殖中的开发应用，2020.10-2023.03，30万元，在研。

2福建省自然科学基金项目，2018J01456，3’UTR的变异区片段对猪繁殖与呼吸综合征病毒的细胞毒力的调控作用，2018.04-2022.03，10万元，在研。

3龙岩市科技项目，2017LY73，闽西猪源猪繁殖与呼吸综合征病毒的细胞毒力被3’非翻译变异区调控的分子机制，2017.04-2019.03，5万元，已结题。

五．代表性论文

1. Guo-Hua Qiu*, Xintian Zheng, Mingjun Fu, Cuiqin Huang, Xiaoyan Yang. The decreased exclusion of nuclear eccDNA: From molecular and subcellular levels to human aging and age-related diseases. Ageing Res Rev. 2021 May; 67:101306.doi: 10.1016/j.arr.2021.101306.

2. Guo-Hua Qiu*, Xintian Zheng, Mingjun Fu, Cuiqin Huang, Xiaoyan Yang. The protective function of non-coding DNA in DNA damage accumulation with age and its roles in age-related diseases. Biogerontology. 2019 Dec; 20(6):741-761.

3. Guo-Hua Qiu*, Cuiqin Huang, Xintian Zheng, Xiaoyan Yang The protective function of noncoding DNA in genome defense of eukaryotic male germ cells. Epigenomics. 2018 Apr 1;10(4):499-517. doi: 10.2217/epi-2017-0103..

4. Guo-Hua Qiu*, Xiaoyan Yang, Xintian Zheng, Cuiqin Huang. The eukaryotic genome is structurally and functionally more like a social insect colony than a book. Epigenomics. 2017, 9 (11):1469-1483. doi: 10.2217/epi-2017-0059.

5. Guo-Hua Qiu*. Genome defense against exogenous nucleic acid in eukaryotes by non-coding DNA through CRISPR-like mechanisms in the cytosol and the bodyguard protection in the nucleus. Mutation Research-Reviews in Mutation Research, 2016, 767: 31-41.

6. Guo-Hua Qiu*. Protection of the genome and central protein-coding sequences by non-coding DNA against DNA damage from radiation. Mutation Research-Reviews in Mutation Research, 2015, 764:108-117.

7. Guo-Hua Qiu, Carol Ho-Wing Leung, Tong Yun, Xiaojin Xie, Mirtha Laban, Shing Chuan Hooi*. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. Molecular Therapy, 2011, 19 (8):1478-86.

8. Guo-Hua Qiu, Manuel Salto-Tellez, James A Ross, Winnie Yeo, Yan Cui, Nicholas Wheelhouse, George G Chen, David Harrison, Paul Lai, Qian Tao, Shing Chuan Hooi*. The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. J Hepatol. 2008; 48(3): 433-41.

9. Guo-Hua Qiu, Huangming Xie, Nicholas Wheelhouse, David Harrison, George G. Chen, Salto-Tellez Manuel, Paul Lai, James A. Ross and Shing Chuan Hooi*. Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. J Hepatol. 2007; 46(4): 655-63.

10. Guo-Hua Qiu, Luke KS Tan, Kwok Seng Loh, Chai Yen Lim, Gopesh Srivastava, Sen-Tien Tsai, SW Tsao, Qian Tao*. The candidate tumor suppressor gene BLU, located at 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene. 2004; 23(27): 4793-4806.